Zeljko J Bosnjak Selected Research

Isoflurane

1/2019	Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning.
1/2018	Failure of Isoflurane Cardiac Preconditioning in Obese Type 2 Diabetic Mice Involves Aberrant Regulation of MicroRNA-21, Endothelial Nitric-oxide Synthase, and Mitochondrial Complex I.
5/2016	High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission.
10/2015	MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway.
4/2015	Up-regulation of microRNA-21 mediates isoflurane-induced protection of cardiomyocytes.
4/2014	Cardioprotection during diabetes: the role of mitochondrial DNA.
3/2013	Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia.
9/2012	Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria.
9/2011	Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning.
4/2008	Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes: roles for mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel activity.

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Zeljko J Bosnjak Research Topics

Disease

19	Ischemia 01/2018 - 07/2002
15	Reperfusion Injury 01/2019 - 08/2003
8	Hypoxia (Hypoxemia) 01/2019 - 07/2002
8	Infarction (Infarctions) 01/2017 - 07/2002
7	Myocardial Ischemia (Ischemic Heart Diseases) 01/2019 - 09/2006
6	Diabetic Cardiomyopathies 01/2021 - 01/2016
6	Myocardial Infarction 01/2019 - 03/2009
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 01/2019
3	Type 2 Diabetes Mellitus (MODY) 01/2021 - 10/2012
3	Learning Disabilities (Learning Disability) 11/2015 - 12/2013
2	Hyperglycemia 05/2016 - 10/2012
2	Diabetes Mellitus 01/2016 - 10/2012
1	Brain Injuries (Brain Injury) 01/2021
1	Neurocognitive Disorders (Clerambault Syndrome) 01/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021
1	Neoplasms (Cancer) 01/2021
1	Inflammation (Inflammations) 10/2018
1	Neoplasm Metastasis (Metastasis) 10/2018
1	Adenocarcinoma of Lung 10/2018
1	Cognitive Dysfunction 01/2018
1	Body Weight (Weight, Body) 01/2018
1	Fibrosis (Cirrhosis) 01/2017
1	Heart Diseases (Heart Disease) 01/2016
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2015
1	Mitochondrial Diseases (Mitochondrial Disease) 03/2014
1	Acidosis 09/2012
1	Teratoma (Teratoid Tumor) 08/2010
1	Pulmonary Atelectasis 01/2009
1	Heart Failure 08/2004

Drug/Important Bio-Agent (IBA)

20	Anesthetics (Anesthetic Agents)IBA 01/2021 - 05/2003
15	Isoflurane FDA LinkGeneric 01/2019 - 07/2002
7	Adenosine Triphosphate (ATP)IBA 03/2013 - 07/2002
4	Long Noncoding RNAIBA 01/2021 - 10/2018
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 10/2012
4	Proteins (Proteins, Gene)FDA Link 01/2017 - 09/2006
3	General AnestheticsIBA 01/2018 - 12/2013
3	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2016 - 09/2011
3	Mitochondrial Permeability Transition PoreIBA 10/2015 - 03/2009
2	Messenger RNA (mRNA)IBA 10/2019 - 01/2019
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 01/2016
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 09/2013
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2018 - 01/2016
2	sapropterin (tetrahydrobiopterin)FDA Link 01/2017 - 01/2016
2	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 01/2017 - 01/2016
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2017 - 10/2015
2	BuffersIBA 01/2016 - 09/2012
2	XenonIBA 09/2013 - 03/2009
2	CalciumIBA 11/2007 - 01/2003
2	Sevoflurane (Ultane)FDA LinkGeneric 09/2006 - 08/2003
2	mitochondrial K(ATP) channelIBA 05/2006 - 05/2003
1	Metformin (Glucophage)FDA LinkGeneric 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	EGF Family of ProteinsIBA 01/2021
1	AnthracyclinesIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2019
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2019
1	Small Interfering RNA (siRNA)IBA 01/2019
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2019
1	Endothelin-1 (Endothelin 1)IBA 01/2019
1	Miat long non-coding RNAIBA 10/2018
1	Blood Glucose (Blood Sugar)IBA 01/2018
1	NAD (NADH)IBA 01/2018
1	p38 Mitogen-Activated Protein KinasesIBA 01/2017
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2017
1	Citric Acid (Citrate)FDA LinkGeneric 01/2016
1	ArginaseIBA 01/2016
1	CitrullineIBA 01/2016
1	Streptozocin (Streptozotocin)FDA Link 01/2016
1	sepiapterinIBA 01/2016
1	serum P-component (CIt)IBA 01/2016
1	Dynamins (Dynamin)IBA 10/2014
1	Mitochondrial DNA (mtDNA)IBA 04/2014
1	Acetylcysteine (Siran)FDA LinkGeneric 04/2014
1	AntioxidantsIBA 04/2014
1	locked nucleic acidIBA 09/2013
1	OligonucleotidesIBA 09/2013
1	NitrogenIBA 09/2013
1	CreatinineIBA 09/2013
1	ProteomeIBA 03/2013
1	Ammonium Chloride (Sal Ammoniac)FDA Link 09/2012
1	DNA (Deoxyribonucleic Acid)IBA 08/2010
1	triphenyltetrazoliumIBA 03/2009
1	Glycogen Synthase Kinase 3 betaIBA 03/2009
1	WortmanninIBA 03/2009
1	Desflurane (I 653)FDA Link 01/2009
1	5-hydroxydecanoic acidIBA 11/2007
1	potassium bromideIBA 09/2006
1	NucleotidesIBA 09/2006
1	SEA 0400IBA 09/2006
1	KATP ChannelsIBA 09/2006
1	2- (2- (4- (4- nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonateIBA 09/2006
1	Pharmaceutical PreparationsIBA 05/2006
1	CaspasesIBA 11/2005
1	Cytochromes c (Cytochrome c)IBA 11/2005
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2005

Therapy/Procedure

3	Therapeutics 01/2021 - 08/2004
2	Anesthesia 01/2021 - 01/2017
1	Bariatric Surgery 01/2009